Jane S. Richardson is a James B. Duke Professor of Biochemistry. She is known for her work with protein structures.
Contains CD and transcript of an oral history interview with Jane S. Richardson. Major subjects in this interview include Richardson's work with her husband in the Dept. of Chemistry at MIT and the Dept. of Biochemistry at Duke University Medical Center, including her work with protein structures and her ribbon drawings. This interview was conducted on 9 November 2007 by Jessica Roseberry.
Contains audiotapes and transcript of an oral history interview with Jane S. Richardson, James B. Duke Professor of Biochemistry.
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Interview Topics Sponsorship: Jane S. Richardson talks about her background; her interest in astronomy; her interest in philosophy; working in the same lab where her husband, Dr. David Richardson, was getting his PhD; in 1969, the laboratory solving the structure of the Staphylococcal nuclease, the tenth protein structure to be determined; her enjoyment of being unknown; working as a technician in the laboratory; what the structure of a protein might tell about that protein; solving the crystal structure of copper/zinc superoxide dismutase at Duke; learning about the geometry of the active site of this enzyme; the significance of knowing the structure of proteins; X-ray crystallography as the technique used then and still used to solve protein structures; the current worldwide Protein Data Bank, which stores about fifty thousand protein structures; her work as a technician; working on computer models of proteins as early as 1960s; current work of the Richardson lab: building tools for determining and analyzing RNA structure; all-atom contact analysis; other people at Duke currently actively working on protein structure, although not the Richardson lab; Jane Richardson being most noted for ribbon drawings of proteins; ribbon drawings outlining the schematics of all known protein structures in 1980; she and her husband not being able to be in the same department due to nepotism rule at the time; creating a uniform set of conventions for the protein ribbon drawings; the freedom to do this work because she was "invisible"; Duke giving her tenure when she became a member of the National Academy of Sciences; common structures depicted in the ribbon drawings; subjectivity of representing protein structures because she outlined the conventions of the drawings; the ubiquitous nature of the ribbon drawings due to computer graphics; current use of the same conventions; her original method of drawing on top of a computer printout of a very simplified protein structure; the laboratory's invention of Kinemages, one of the first molecular graphics systems available on personal computers; the current size of the laboratory; Duke in the 1970s; Dr. Robert Hill; women as being "on the edges" of the department; her own unusual career track; not getting a PhD; this fact embarrassing the university once she became well-known; receiving a MacArthur Fellowship because of the ribbon drawings; her own circuitous route as being useful; the collaborative nature of her work with her husband; the difficulty in current scientific culture of collaborating, since the tenure emphasis is on receiving credit for something; change in the nepotism rule; pairs of scientists; the connectivity of the current field due to computers; pressure as one result of connectivity; and her enjoyment of having many female colleagues currently. The transcription of this interview was made possible by a grant from the Josiah Charles Trent Memorial Foundation.
[Identification of item], Jane S. Richardson Interview, Duke University Medical Center Archives.
Acquired; 9 November 2007.
Processed by Jessica Roseberry, June 2008 Encoded by Dawne Howard Lucas, September 2008